If you can be in a city with wide-open senses, you're capable of something I am absolutely not.
I can do it, and have done it, for long periods, but it was very, very unpleasant.
So I would say, no, you can't; at least not comfortably or constructively.
In my case, such a state led inexorably to depression.
And, on a lighter note: I haven't been depressed in years, and seem completely immune to it now.