Or, as it was later translated "On Nature". This was the original title of Heraclitus's fragments and reflects much more deeply on the essence of what it means to live. In fact, the translational scheme from "On Nature" to "A helm unerring" is of the greatest import.
Now what does this imply? This was a guideline for those capable of living by life's own rules- without the pro/con or moral thinking that colors men of lower status (as Heraclitus might have put it). This mode of thinking is the closest to the traditional Nihilistic paradigm. If we are to live then we cannot live under any presumption. We must live in line with life.
A big portion of this is eradicating the 'telos' from your depiction of how to live. *Just* live. Otherwise, you live on a balancing scale, "Be wary of gazing into the abyss, for if you gaze too long it gazes back into you."
Having goals is different from living according to a nebulous telos you are to fulfill. By positing this telos before you have started to *live* you are already fighting a losing game. Merely by living according to the rule of life, you have fulfilled everything that needs to be fulfilled.
The point is not to conquer life, but mould yourself to the rule of the world- nay, the universe. In doing so, you have already conquered the most dangerous of all foes.