You'd need:
1. a computer that auto-runs USB sticks
2. an unmonitored computer that allows you to log on/have access to system files
3. a virus scanner that doesn't pick up a "too large, too encrypted (lol), too complex" files
It's all hype. Anyone with knowledge on how to prevent infections knows exactly how to counter such software. Sadly/luckily, most people don't know.